Polyurethane foam... Sounds like a good material, can you add more when you take too much off in the process of sculpting? I guess you are right about the weight.
Also the detail - is it possible to have a foam without any large air bubbles? I suppose there is different foam chemistry to chose from. Matte finish is ok because the part will painted afterwards for gloss finish. Also - some positive moulds will be composed of both native car body and new added material, so the parts won't be taken off for the process of negative mould preparation. Maybe this picture explains it better, this is a part of the design (it's raw without any photoshop fireworks). As you see the rear fender is partially made of clay and partially made of the native car skin. Transition is supposed to be seamless to produce a single panel. In reality it adds 7cm per side.

I think I need ribs for this, just like you mention the symmetry problem.
I will add more pictures as I go, obtaining the design in 1:18 scale took a month already and I think I got it, but need to clean up the pictures in photoshop before sharing.
Thanks again!