Yeh, you should wear gloves. Not only because it is a chemical and unhealthy, but because it is a solvent it will dissolve the oils on your hands and deposit it in the surface of your mould, leaving streaks.
You should also use a new cloth for each and every application. I know it seems like a waste, but again it will affect your surface finish. What happens is you apply your coat, and then leave the remainder of the release agent to partially cure in the cloth. Then you apply more release agent to the cloth, and again the solvents dissolve that partially cured release agent and deposit it on your mould surface, leaving streaks. If you want a more economical approach, use the lint-free solvent application wipes from Easy Composites, and cut each cloth into 8 pieces. This will give you enough wipes to do a full application on anything you are moulding, and it will also help regulate how heavy you are applying the release agent as obviously there is less cloth and it cant hold as much.
Which brings me to my final point. You dont want to over apply a chemical release agent. You only want a film that is just wet enough to leave a film behind as you wipe it on, before it evaporates 5 seconds or so later. If you can coat your entire mould before the film starts to evaporate, it's too heavy and it will leave streaks and can actually cause poor release as the liquid beads up. This may feel tedious as you need to reapply the release agent to your application cloth several times for a mould, but it will improve your surface finishes and release performance.